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New publication in Nature Communications
25.09.2025
Molecular basis of ParA ATPase activation by the CTPase ParB during bacterial chromosome segregation
Lucas Schnabel, Manuel Osorio-Valeriano, Cecilia Perez-Borrajero, Wieland Steinchen, Christopher-Nils Mais, Bernd Simon, Juri Hanßmann, Maria Thamm, Janosch Hennig, Gert Bange & Martin Thanbichler
The group of Martin Thanbichler (Marburg) could decipher the molecular basis of ParA ATPase activation by ParB. This molecular mechanisms is essential for DNA transport by the ParABS system and therefore bacterial chromosome segregation during cell division in the majority of bacteria. We contributed NMR data that identifies and confirms the binding interface of ParB on ParA.