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In this publication published today in Cell Reports (doi.org/10.1016/j.celrep.2025.116492), we could improve our understanding of the mechanisms in translation regulation, one of our main projects. We teamed up with Olivier Duss at the EMBL to utilise their expertise in single molecule fluorescence microscopy (total internal reflection fluorescence microscopy, TIRF) to now have a near complete understanding on how this quaternary RNA binding protein complex assembles on its specific target mRNA msl2. Proper assembly is essential for viability of females. This is really exciting and gives a lot of new insights into how mRNPs assemble and goes beyond canonical RNA binding by RRM-containing proteins. You can also watch Marco Payr’s video below and marvel at his design artistry (journal cover suggestion and graphical abstract).